Aired: 2003-2023 Cartoon Network 
DAD #1: Dr. Rusty Venture (James Urbaniak) / Widower
DAD #1’S JOB: Scientist
KIDS OF DAD #1: Hank (Christopher McCulloch), Dean (Michael Sinterniklaas)(teens — although…)
WHERE’S MOM #1?: they “don’t have a mom” (pilot ep) SPOILER: You find out in the movie finale!
STAND-IN “MOM #1”: Brock Sampson (Patrick Warburton) / Bodyguard
DAD #2: Dr. Byron Orpheus (Steve Ratazzi) / Divorced
DAD #2’S JOB: Necromancer
KIDS OF DAD #2: Triana (Lisa Hammer)(teen)
WHERE’S MOM #2?: Wife ran off with a younger necromancer
STAND-IN “MOM #2”: None identified
Right down to the Robot-Eye-on-Stilts in the opening credits, this is a spot-on parody of Jonny Quest.
Patrick Warburton (of the live-action The Tick fame) gets the plum assignment of voicing the Race Bannon character.
In Season 2, we learn that Hank and Dean are clones, and have had as many as sixteen previous “renditions” – – all have whom met horrifying deaths from either enemies of Doc Venture, or just unfortunate household accidents involving booby-traps or hoverbike mishaps
Here’s a rundown from Alert Viewer Cassidy Peterson, who gets the tag on spotting this series:
Father is Dr. Rusty Venture, sons Hank & Dean. Their mother has only been mentioned once, and explanation was prevented by the “convenient distraction” ploy, in this case Dr. Venture’s date leaning on her car horn outside. He did, however, seem hesitant to respond, although he was prepared to speak before being interrupted and leaving. (episode where mother is mentioned: Mid-Life Chrysalis)
Side characters include Dr. Orpheus, who is renting extra space from Dr. Venture. Orpheus is another single dad! His daughter is the gothic Triana. Mother has not been mentioned as of yet. (Orpheus & Treana are introduced in episode: Eeney, Meeny… Magic!)