Aired: 1983-85 
DAD: Inspector Gadget (voice of Don Adams) / Single Guy / Uncle 
DAD’S JOB: Police Inspector
KIDS: Penny (voice of Holly Berger [1983], then Cree Summer [1984-85]) (10)
WHERE’S MOM?: Don’t know. Dad’s whereabouts a mystery, too.
STAND-IN "MOM": Perhaps Brain, the dog (voice of Frank Welker)
Nancy Drew, except it’s (a) a cartoon, and (b) the single uncle is a RoboCop-like semi-android.
Another good analogy is Remington Steel, where the female character is the power behind the image. However, the Remington Steel character actually had a brain in his head, compared to the Inspector Clouseau-like Gadget.